人物经历

学习经历

工作经历

研究方向

• Disease Proteomics: Biomarker discovery and validation.
  
• Drug Proteomics: Drug action mechanism and target discovery.
  

学术成果

主要论文

1. Yang J, Li B,He QY. “Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.”Cell Death Dis. doi: 10.1038/s41419-018-0661-3. (IF = 5.965)
   
2. Liu WT, Wang Y, Zhang J, Ye F, Huang XH, Li B,He QY. “A novel strategy of integrated microarray analysis identifies CENPA, CDK1 and CDC20 as a cluster of diagnostic biomarkers in lung adenocarcinoma.”Cancer Lett. doi:10.1016/j.canlet.2018.03.043. (IF = 6.375)
   
3. Xu WW, Li B, Zhao JF, Yang JG, Li JQ, Tsao SW,He QY, Cheung ALM. “IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness.”Cancer Lett.doi: 10.1016/j.canlet.2018.03.039. (IF = 6.375)
   
4. Zhang J, Wang Y, Zhou Y,He QY. “Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca2+-mitochondria dependent pathway.”Oncotarget. doi: 10.18632/oncotarget.20077. (IF = 5.168)
   
5. Zhong Y, Yang J, Xu WW, Wang Y, Zheng CC, Li B,He QY. “KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.”Oncogene. doi: 10.1038/onc.2017.287. (IF = 7.519)
   
6. Zhang J, Lu SH, Zhou Y, Meng K, Chen ZP, Cui YZ, Shi YF, Wang T,He QY. “Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.”Proteomics. doi: 10.1002/pmic.201700103. (IF = 4.041)
   
7. Wang Y, Zhang J, Huang ZH, Huang XH, Zheng WB, Yin XF, Li YL, Li B,He QY. “Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop.”Cell Death Dis. doi: 10.1038/cddis.2017.265. (IF = 5.965)
   
8. Li B, Xu WW, Lam AKY, Wang Y, Hu HF, Guan XY, Qin YR, Saremi N, Tsao SW,He QY, Cheung ALM. “Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.”Oncotarget. doi: 10.18632/oncotarget.16333. (IF = 5.168)
   
9. Li B, Xu WW, Han L, Chan KT, Tsao SW, Lee NP, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY,He QY, Cheung AL. “MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF.”Oncogene. doi: 10.1038/onc.2017.29. ( IF = 7.519)
   
10. Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW,He QY, Cheung AL. “Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.”Nat Commun. doi: 10.1038/ncomms14399. (IF = 12.124)
    
11. Gao XJ, Feng JX, He YJ, Xu FM, Fan XQ, Huang WS, Xiong HT, Liu QY, Liu WT, Liu XH, Sun XS,He QY, Zhang QH, Liu LX. “hnRNPK inhibits GSK3beta Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.”Sci Rep. doi: 10.1038/srep22999. (IF = 4.259)
    
12. Li B, Xu WW, Guan XY, Qin YR, Law S, Lee NP, Chan KT, Tam PY, Li YY, Chan KW, Yuen HF, Tsao SW,He QY, Cheung AL. “Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.”Clin Cancer Res. doi: 10.1158/1078-0432.CCR-15-1196. (IF = 9.619)
    
13. Lian XL, Guo JH, Gu W, Cui YZ, Zhong JY, Jin JJ,He QY, Wang T, Zhang G. “Genome-Wide and Experimental Resolution of Relative TranslationlGene Level in Human Cells.”PLoS Genet.doi: 10.1371/journal.pgen.1005901. (IF = 6.1)
    
14. Yang XY, He K, Du GF, Wu XH, Yu GC, Pan YL, Zhang G, Sun XS,He QY. “Integrated Translatomics with Proteomics to Identify Novel Iron-Transporting Proteins inStreptococcus pneumoniae.”Front Microbiol. doi: 10.3389/fmicb.2016.00078. (IF = 4.076)
    
15. Chen ZP, Yang LJ, Cui YZ, Zhou YL, Yin XF, Guo JH, Zhang G, Wang T,He QY. “Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.”Oncotarget. doi: 10.18632/oncotarget.11794. (IF = 5.168)
    
16. Zhong J, Xiao C, Gu W, Du G, Sun X,He QY, Zhang G. “Transfer RNAs Mediate the Rapid Adaptation ofEscherichia colito Oxidative Stress.”PLoS Genet. doi: 10.1371/journal.pgen.1005302. (IF = 6.1)
    
17. Yu G, Wang LG,He QY. “ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization.”Bioinformatics. doi: 10.1093/bioinformatics/btv145. (IF = 7.307)
    
18. Yu G, Wang LG, Yan GR,He QY. “DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis.”Bioinformatics. doi: 10.1093/bioinformatics/btu684. (IF = 7.307)
    
19. Li B, Tsao SW, Chan KW, Ludwig DL, Novosyadlyy R, Li YY,He QY, Cheung AL. “Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance-Implications for IGF-II and IGF-IR-Targeted Therapy.”Clin Cancer Res. doi:10.1158/1078-0432.CCR-13-2735. (IF = 9.619)
    
20. Wang T, Cui Y, Jin J, Guo J, Wang G, Yin X,He QY, Zhang G. “Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.”Nucleic Acids Res. 2013 May;41(9):4743-54. doi: 10.1093/nar/gkt178. (IF = 10.162)
    

承担课题

1. 蛋白质修饰组的高维度鉴定及其功能网路，国家重点研发计画重点专项项目（2017YFA0505100），3124万元，2017/7-2022/6，主持。
   
2. 细胞周期调节因子KCTD12的发现及其调控机制，国家自然科学基金面上项目（31770888），60万元，2018/1-2021/12，主持。
   
3. 人类新蛋白UBAP1-AST6的发现及其功能研究，国家自然科学基金面上项目（31570828），62万元，2016/1-2019/12/1，主持。
   
4. 功能蛋白质研究与抗癌药物靶标发现，广东省自然科学基金团队项目（S2013030013315），200万元，2013/10/1-2018/10/1，主持。
   

荣誉奖励