海之美文新闻资讯
梁琼麟
梁琼麟，清华大学长聘副教授、博士生导师
以微流控学为基础，发展微纳流体操控的新原理新技术，并将其套用于微纳尺度的输运、组装和生物製造，模拟组织器官的微结构和微环境，结合原位光谱成像分析和质谱联用分析等检测技术，构建生命分析和生物医学研究的新模型，发展微流控生命分析的原理、方法及装置，参与生命科学前沿基础研究，服务于药物研发、临床检测等国家重大需求。研究重点方向包括组织器官晶片、单细胞亚细胞分析晶片及临床组学分析与生物标誌物检测的微流控晶片系统研製。主持承担国家自然科学基金项目，国家重大科技专项课题，国家973计画和重点研发计画计画子课题等多项国家科研任务。发表SCI论文150余篇，他引3000余次。以共同作者出版学术着作5部, 获得授权中国发明专利十余项。部分研究成果在合作的製药企业、临床医院得到一定套用，曾共同获得国家科技进步二等奖3项。
基本介绍
- 中文名：梁琼麟
- 国籍：中国
- 民族：汉
- 出生地：湖南
- 职业：教师
- 毕业院校：清华大学
- 信仰：共产主义
- 主要成就：共同获得国家科技进步二等奖3项
人物经历
学习经历
1996.9 - 2000.7 清华大学化学系化学专业 理学学士
2000.9 - 2005.7 清华大学化学系分析化学 理学博士
2000.9 - 2005.7 清华大学化学系分析化学 理学博士
工作履历
2005.8 - 至今， 清华大学化学系 历任讲师，副教授
2008 年聘任硕士生导师，2012 年被聘任为博士生导师
2005 年 8 月任研究生工作组组长，
2012 年 11 月任化学系党委副书记，
2015 年 4 月任化学系党委书记，
2016 年获聘教研系列长聘副教授。
社会任职
中国化学会青年化学工作者委员会委员
北京理化分析测试技术学会青委会理事长
中国分析测试协会青委会副主任委员
中国医药生物技术协会药物分析技术分会常务委员兼秘书长
中国中药协会中药产品培育与开发专业委员会副主任委员
主要成就
科研成就
科研综述：
在以微流控学为基础，发展微纳流体操控的新原理新技术，并将其套用于微纳尺度的输运、组装和生物製造，模拟组织器官的微结构和微环境，结合原位光谱成像分析和质谱联用分析等检测技术，构建生命分析和生物医学研究的新模型，发展微流控生命分析的原理、方法及装置，参与生命科学前沿基础研究，服务于药物研发、临床检测等国家重大需求。研究重点方向包括组织器官晶片、单细胞亚细胞分析晶片及临床组学分析与生物标誌物检测的微流控晶片系统研製。主持承担国家自然科学基金项目，国家重大科技专项课题，国家973计画和重点研发计画计画子课题等多项国家科研任务。发表SCI论文150余篇，他引3000余次。以共同作者出版学术着作5部, 获得授权中国发明专利十余项。部分研究成果在合作的製药企业、临床医院得到一定套用，曾共同获得国家科技进步二等奖3项。
奖励荣誉
2018 世界中医药学会联合会中医药国际贡献奖-科技进步二等奖（2/10）
2016 国家科技进步二等奖（3/10）
2015 中华中医药学会科学技术进步一等奖(3/15)
2014 国家科技进步二等奖(8/10)
2014 清华大学第十四届“良师益友”
2013 教育部新世纪优秀人才支持计画
2012 北京市科技进步二等奖（4/10）
2012 河北省科技进步一等奖（7/10）
2011 上海市科技进步一等奖（12/15）
2011 The PSC (Permanent Scientific Committee of HPLC Symposium) Young Scientist Lecture Award
2010 河北省医药科学技术进步一等奖（6/10）
2009 清华大学“先进工作者”称号
2007 国家科学技术进步二等奖(7/10)
学术成果
近三年代表性论文（Selected Recent Publications）：
1. Xie RX, Xu PD, Liu YP, Li LL, Luo GA, Ding MY and Liang QL*. Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process. Advanced Materials, 2018, 30: 1705082.
2. Zhang F, Xiong LG, Ai YJ, Liang Z and Liang QL*. Stretchable Multi-responsive Hydrogel with Actuatable, Shape memory and Self-healing Properties. Advanced Science, 2018, 5: 1800450.
3. Li LL, Li YQ, Shao ZX, Luo GA, Ding MY and Liang QL*. Simultaneous Assay of Oxygen-Dependent Cytotoxicity and Genotoxicity of Anticancer Drugs on an Integrated Microchip. Analytical Chemistry, 2018,90（20）：11899-11907. (cover feature)
4. Ma LD, Wang YT, Wang JR, Wu JL, Meng XS, Hu P, Mu X, Liang QL* and Luo GA*. Design and Fabrication of a Liver-on-a-chip Platform for Convenient, Highly Efficient, and Safe in Situ Perfusion Culture of 3D Hepatic Spheroids. Lab on a Chip, 2018, 18: 2547 -2562.
5. Ai YJ, Liu L, Zhang C, Qi L, He MQ, Liang Z, Sun HB*, Luo GA and Liang QL*. Amorphous Flowerlike Goethite FeOOH Hierarchical Supraparticles: Superior Capability for Catalytic Hydrogenation of Nitroaromatics in Water. ACS Applied Materials & Interfaces, 2018, 10: 32180-32191.
6. Yang SH, Zhang FF, Liang QL* and Wang ZH*. A Three-Dimensional Graphene-Based Ratiometric Signal Amplification Apta sensor for MUC1 Detection. Biosensors & Bioelectronics,2018, 120: 85-92.
7. Yang SH, Zhang FF, Wang ZH* and Liang QL*. A Graphene Oxide-based Label-free Electrochemical Aptasensor for the Detection of Alpha-fetoprotein. Biosensors & Bioelectronics, 2018, 112: 186-192.
8. Ai YJ, He MQ, Zhang F, Long Y, Li YZ, Han Q, Ding MY, Sun HB* and Liang QL*. Metallo-supramolecular Polymer Engineered Porous Carbon Framework Encapsulated Stable Ultra-small Nanoparticles: a General Approach to Construct Highly Dispersed Catalysts. Journal of Materials Chemistry A, 2018, 6: 16680-16689.
9. Long Y, Han Q, Yang ZQ, Ai YJ, Sun SA, Wang Y, Liang QL * and Ding MY*. A Novel Solvent-free Strategy for the Synthesis of Bismuth Oxyhalides. Journal of Materials Chemistry A, 2018, 6: 13005-13011. (cover feature)
10. Ai YJ, Hu ZN, Shao ZX, Qi L, Liu L, Zhou JJ, Sun HB* and Liang QL*. Egg-like Magnetically Immobilized Manospheres: A Long-lived Catalyst Model for the Hydrogen Transfer Reaction in a Continuous-flow Reactor. Nano Research, 2018, 11: 287–299.
11. Liang Z, Liu, YP, Zhang F, Ai YJ and Liang QL*, Dehydration-triggered Shape Morphing Based on Asymmetric Bubble Hydrogel Microfibers. Soft Matter, 2018, 14: 6623-6626. (cover feature)
12. Liu L, Liu YH*, Ai, YJ, Li JF, Zhou JJ, Fan ZB, Bao HJ, Jiang RH, Hu ZN, Wang JT, Jing K, Wang Y, Liang QL* and Sun HB*. Pd-CuFe Catalyst for Transfer Hydrogenation of Nitriles: Controllable Selectivity to Primary Amines and Secondary Amines,iScience, 2018, 8: 61-73.
13. Wang JD, Tan SY, Liang QL*, Sun SA, Han Q, Ding MY*. Preparation of magnetic microspheres functionalized by lanthanide oxides for selective isolation of bovine hemoglobin. TALANTA 2018, 190: 210-218
14. Bao HJ, Li YN, Liu L, Ai YJ, Zhou JJ, Qi L, Jiang RH, Hu ZN, Wang JT, Sun HB*, and Liang QL*. Ultrafine FeCu Alloy Nanoparticles Magnetically Immobilized in Amine‐Rich Silica Spheres for Dehalogenation-Proof Hydrogenation of Nitroarenes. Chemistry-A European Journal, 2018, 24: 14418-1442.
15. Hu ZN, Zhou, JJ, Ai YJ, Liu L, Qi L, Jiang RH, Bao HJ, Wang JT, Hu JS, Sun HB* and Liang QL*. Two Dimensional Rh/Fe3O4/g-C3N4-N Enabled Hydrazine Mediated Catalytic Transfer Hydrogenation of Nitroaromatics: A Predictable Catalyst Model with Adjoining Rh. Journal of Catalysis, 2018, 368: 20-30.
16. Han Q, Aydan T, Yang L, Zhang XQ; Liang QL* and Ding MY*. In-syringe Solid-phase Extraction for On-site Sampling of Pyrethroids in Environmental Water Samples. Analytica Chimica Acta,2018, 1009: 48-55.
17. Wang WX, Li LL*, Ding MY, Luo GA and Liang QL*. A Microfluidic Hydrogel Chip with Orthogonal Dual Gradients of Matrix Stiffness and Oxygen for Cytotoxicity Test. BioChip Journal, 2018, 12: 93-101.
18. Wang JT, Chen YX, Zhang ZQ, Ai YJ, Liu L, Qi L, Zhou JJ, Sun HB*, Niu D* and Liang QL*. Microwell Confined Iron Oxide Nanoparticles in Honeycomblike Carbon Spheres for the Adsorption of Sb (III) and Sequential Utilization as a Catalyst. ACS Sustainable Chemistry & Engineering, 2018, 6: 12925-12934.
19. Ai YJ, He MQ, Lv QR, Liu L, Sun HB*, Ding MY and Liang QL*. 3D Porous Carbon Framework Stabilized Ultra-Uniform Nano γ-Fe2O3: A Useful Catalyst System. Chemistry-An Asian Journal, 2018, 13,89–98.
20. Tan SY, Wang JD, Han Q, Liang QL* and Ding MY*. A Porous Graphene Sorbent Coated with Titanium (IV)-Functionalized Polydopamine for Selective Lab-in-syringe Extraction of Phosphoproteins and Phosphopeptides. Microchimica Acta, 2018, 185: 316-326.
21. Li YZ, Xiong JL, Shao ZX, Ai YJ, Hua RM, Luo GA and Liang QL*. An Asymmetrical Cyanine Dye Nanoparticles for Small Vessel Photoacoustic Imaging In Vivo. ChemNanoMat, 2018, 4, 626-630.
22. Liu CG, Zheng WC, Xie RX, Liu YP, Liang Z, Luo GA, Ding MY and Liang QL*. Microfluidic Fabrication of Water-in-water Droplets Encapsulated in Hydrogel Microfibers. Chinese Chemical Letters, 2018, in press, DOI: 10.1016/j.cclet.2018.09.010.
23. Fan XM, Huang, CL, Wang, YM, Li N, Liang QL, and Luo GA*. Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in db/db Mice Using Cytokine Antibody Array. Journal of Diabetes Research, 2018, 2018: Article ID 8237590, 10 pages.
24. Liu YP, Xu PD, Liang Z, Xie RX, Ding MY, Liu HX and Liang QL*. Hydrogel Microfibers with Perfusable Folded Channels for Tissue Constructs with Folded Morphology. RSC Advances, 2018, 8: 23475-23480.
25. Wang JD, Tan SY, Liang QL*, Sun SA, Han Q and Ding MY*. Preparation of Magnetic Microspheres Functionalized by Lanthanide Oxides for Selective Isolation of Bovine Hemoglobin. Talanta, 2018, 190: 210-218.
26. Xu PD, Xie RX, Liu YP, Li LL, Luo GA, Ding MY and Liang QL*. Bioinspired Microfibers with Embedded Perfusable Helical Channels. Advanced Materials, 2017, 29: 1701664. (cover feature)
27. Huang ZQ, Fan XM*, Wang YM, Liang QL, Tong XL, Bai Y, Li YM, Luo GA and Chen C*. A New Method to Evaluate the Dose-effect Relationship of a TCM Formula Gegen Qinlian Decoction: “Focus” Mode of Integrated Biomarkers. Acta Pharmacologica Sinica, 2017, 8: 1141-1149.
28. Zhou JJ, Li YN, Sun HB*, Tang ZK, Qi L, Liu L, Ai YJ, Li S, Shao ZX andLiang QL*. Porous Silica-Encapsulated and Magnetically Recoverable Rh NPs: A Highly Efficient, Stable and Green catalyst for Catalytic Transfer Hydrogenation with “Slow-release” of Stoichiometric Hydrazine in Water. Green Chemistry, 2017, 19: 3400-3407.
29. Ai YJ, Liu L, Jing K, Qi L, Fan ZB, Zhou JJ, Sun HB*, Shao ZX and Liang QL*. Noncovalently Functionalized Carbon Nanotubes Immobilized Fe–Bi Bimetallic Oxides as a Heterogeneous Nanocatalyst for Reduction of Nitroaromatics. Nano-Structures & Nano-Objects, 2017, 10: 116-124.
30. Han Q, Yang L, Liang QL* and Ding MY*. Three-Dimensional Hierarchical Porous Graphene Aerogel for Efficient Adsorption and Preconcentration of Chemical Warfare Agents.Carbon, 2017, 122: 556-563.
31. Liu L, Ai YJ, Li D, Qi L, Zhou JJ, Tang ZK, Shao ZX, Liang QL* and Sun HB*. Recyclable Acid-Base Bifunctional Core-Shell-Shell Nanosphere Catalyzed Synthesis of 5-Aryl-1H-1,2,3-triazoles through the “One-Pot” Cyclization of Aldehydes, Nitromethane, and Sodium Azide. ChemCatChem, 2017, 9: 3131-3137.
32. Qi L, Li YN, Liu L, Zhou JJ, Ai YJ, Tang ZK, Wang JT, Bao HJ, Zhang C, Liang QL, Sun HB* and Niu D*. Immobilizing Multifunctional Fe2O3-SnO2 Nanoparticles to Carbon Nanospheres: An Extremely Active and Selective Catalyst for Hydrogen Transfer Reaction. ChemistrySelect, 2017, 2: 8288-8295.
33. Sun HB*, Ai YJ, Li D, Tang ZK, Shao ZX and Liang QL*. Bismuth Iron Oxide Nanocomposite Supported on Graphene Oxides as the Highly Efficient, Stable and Reusable Catalysts for the Reduction of Nitroarenes Under Continuous Flow Conditions. Chemical Engineering Journal, 2017, 314: 328-335.
34. Xu Y, Tan SY, Liang QL* and Ding MY*. One-Step Facile Synthesis of Aptamer-Modified Graphene Oxide for Highly Specific Enrichment of Human A-Thrombin in Plasma. Sensors, 2017, 17: 1986-1996.
35. Yan M, Liang QL*, Wan W, Han Q, Tan SY and Ding MY*. Amino Acid-modified Graphene Oxide Magnetic Nanocomposite for the Magnetic Separation of Proteins. RSC Advances, 2017, 7: 30109-30117.
36. Zhou BJ, Li YZ, Niu GL, Lan MH, Jia QY, Liang QL*. Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer. ACS Applied Materials & Interfaces, 2016, 8: 29899-29905.
37. Li LL, Wang WX, Ding MY, Luo GA and Liang QL*. Single-Cell-Arrayed Agarose Chip for in Situ Analysis of Cytotoxicity and Genotoxicity of DNA Cross-Linking Agents. Analytical Chemistry, 2016, 88: 6734-6742.
38. Liang Z, Liu CG, Li LL, Xu PD, Lu GA, Ding MY andLiang QL*. Double-Network Hydrogel with Tunable Mechanical Performance and Biocompatibility for the Fabrication of Stem Cells-Encapsulated Fibers and 3D Assemble. Scientific Reports, 2016, 6: 33462.
39. Zhang F, Gao D* and Liang QL*. Advances of Microfluidic Technologies Applied in Bio-analytical Chemistry. Chinese Journal of Analytical Chemistry, 2016, 12: 1942-1949.
40. Xie YY, Wang XM, Wang SH, Wang YM, Tian HF, Yuan YS, Li HY,Liang QL* and Luo GA*. Metabolism and Pharmacokinetics of Major Polyphenol Components in Rat Plasma After Oral Administration of Total Flavonoid Tablet from Anemarrhenae Rhizoma. Journal of Chromatography B, 2016, 1026: 134-144
41. Li YQ, Li LL, Liu ZX, Ding MY, Luo GA and Liang QL*. A Microfluidic Chip of Multiple-channel Array with Various Oxygen Tensions for Drug Screening. Microfluidics and Nanofluidics, 2016, 20, 97-106.
42. Zhu C*, Liang QL, Wang YM, Luo GA, Vreeken RJ and Hankmeimer T. Advance in Analysis and Detection Technologies for Phospholipidomics. Chinese Journal of Analytical Chemistry, 2016, 44: 984-992.
43. Han Q,Liang QL*, Zhang XQ, Yang L and Ding MY*. Graphene Aerogel Based Monolith for Effective Solid-phase Extraction of Trace Environmental Pollutants from Water Samples. Journal of Chromatography A, 2016, 1447: 39-46.
44. Wan W, Liang QL*, Zhang XQ, Yan M and Ding MY*. Magnetic Metal-Organic Frameworks for Selective Enrichment and Exclusion of Proteins for MALDI-TOF MS Analysis. Analyst, 2016, 141: 4568-4572.
45. Wang H, Liang XP, Luo GA, Ding MY and Liang QL*. Protection Effect of Nicotinamide on Cardiomyoblast Hypoxia/re-oxygenation Injury: Study of Cellular Mitochondrial Metabolism. Molecular BioSystems, 2016, 12: 2257-2264.
46. Zhang XQ, Liang QL*, Han Q, Wan W and Ding MY*. Metal-Organic Frameworks @Graphene Hybrid Aerogels for Solid-Phase Extraction of Nonsteroidal Anti-inflammatory Drugs and Selective Enrichment of Proteins. Analyst, 2016, 141: 4219-4226.